Scramblases catalyze the movement of lipids between both leaflets of a bilayer.Whereas the X-ray structure of the protein nhTMEM16 has previously revealed the architecture of a Ca2+-dependent lipid scramblase, its regulation mechanism has remained elusive.Here, we have used cryo-electron microscopy and functional assays to address this question.Ca2
Lung adenocarcinomas from patients who respond to the tyrosine kinase inhibitors gefitinib (Iressa) or erlotinib (Tarceva) usually harbor somatic gain-of-function mutations in exons encoding the kinase domain of the epidermal growth factor receptor (EGFR).Despite initial responses, patients eventually progress by unknown mechanisms of "acquired" re
Abstract This article discusses non-isolated, trans-inverse, coupled inductor (CI)-based, soft-switching, high-gain DC-to-DC converter topology for renewable sources.The three-winding CI Console Cable is utilized to achieve a high voltage gain with a reduced turns ratio.The energy associated with the magnetic components is recycled by the passive c
Given the relationship between social cognition and functional outcome in schizophrenia, a number of social cognitive interventions have been developed, including Social Cognition Interaction Training (SCIT), a group-based, comprehensive, manualized intervention.In the current trial, we examined SCIT efficacy as well as potential moderators of trea